Novel Inhalational Murine Model of Invasive Pulmonary Aspergillosis
نویسندگان
چکیده
منابع مشابه
Standardization of an experimental murine model of invasive pulmonary aspergillosis.
Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.
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SUMMARY Aspergillosis is an infectious disease caused by genus aspergillos species. Aspergilli are ab undant in the environment, they Jive in soil as saprophyte deriving nutrient, from dead plants and animal matters. The genus aspergillos in characterized by the formation of distinctive conidiophores giving rise to conidias which can spread by air and are able to reside on the body surface spe...
متن کاملAntifungal prophylaxis is effective against murine invasive pulmonary aspergillosis.
Antifungal prophylaxis for patients at high risk for aspergillosis is appealing due to the high morbidity and mortality of aspergillosis despite antifungal therapy (1–3). While voriconazole is a logical option, reports of breakthrough mucormycosis are a cause for concern (5). To identify alternative prophylactic strategies, we utilized our novel, inhalational model of pulmonary Aspergillus fumi...
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Here we report a case of co-infection of hydatid cyst with invasive apergillosis, in a previously healthy, non immunocompromised, 26year old man. Chest x-ray revealed a large cystic cavity in left upper lobe of lung histopathologic examination of the specimen confirmed the diagnosis of hydatid cyst with numerous fungal hyphea which invaded the laminated wall of the cyst. Although, co-infection ...
متن کاملInvasive Pulmonary Aspergillosis*
A prospective study was conducted in 38 patients with nodular lesions on plain chest radiographs and the clinical suspicion of invasive pulmonary aspergillosis (IPA) to assess the diagnostic accuracy of magnetic resonance imaging (MRI) and computed tomography (CT). For early diagnosis of IPA (clinical signs and symptoms <10 days), CT scans with demonstration of the halo sign had a high sensitiv...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2004
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.48.5.1908-1911.2004